"ototoxicity" will initially complain of tinnitus or ringing in the
ears due to damage of sensory cells within the inner ear. If the
underlying cause is not eliminated then the patient may go on to develop
hearing loss. Furthermore, this can result in changes in balance, gait,
and overall quality of life. The following medications are most commonly
known to increase the risk for ototoxicity (i.e., hearing loss).
Known to be Ototoxic:
- Tobramycin (TOBI; Tobrex)
- Cisplatin (Platinol)
- Loop Diuretics
- Bumetanide (Bumex)
- Furosemide (Lasix)
- Torsemide (Demadex)
- Quinine (Qualaquin)
- Telavancin (Vibativ)
with any side effect of a medication, not all patients will experience this
problem, however in certain situations it can manifest or be something to
monitor for. For example, using two or more medications with risk for
ototoxicity. Another example is using too high of a dose for too long of
a period of time, which would increase exposure of the drug to the tissue as
sometimes seen with aminoglycosides. So it needs to be put in context to
the use of the medication(s) and in relation to its cost to benefit ratio.
If you know of other medications that should be
added to this list, please let us know. We appreciate your
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