Summary:

• It appears from several studies, meta-analysis, and use across several different indications, that topical chlorhexidine-gluconate-70% isopropyl alcohol solution applied to the skin is more effective than povidone-iodine (Betadine) at preventing skin or wound infections when used prior to an invasive or surgical procedure.
• This beneficial effects of chlorhexidine over povidone-iodine (Betadine) may have to do with chlorhexidine's rapid onset of action and continued efficacy despite the skin being exposed to bodily fluids that could deactivate iodine containing topical antiseptic agents.

Editors: 

• Anthony J. Busti, MD, PharmD, MSc, FNLA, FAHA
• Dylan Kellogg, MD