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Lab Test: Copper (Blood) Level

    Lab Test
    • Copper (Blood)
    Description
    • Measurement of copper in serum for evaluation of copper deficiency, toxicity, and disorders of copper metabolism.
    Reference Range
    • Adults:  70-140 mcg/dL (11-22 micromol/L)
    • Infants, 0 to 6 months:  20-70 mcg/dL (3.1-11 micromol/L)
    • Children, 6 years:  90-190 mcg/dL (14.1-29.8 micromol/L)
    • Children, 12 years:  80-160 mcg/dL (12.6-25.1 micromol/L)
    • Pregnancy (at term):  118-302 mcg/dL (18.5-47.4 micromol/L)
    • Levels in African-Americans are 8% to 12% higher
    Indications & Uses
    • Pregnancy complications secondary to suspected copper deficiency - severe maternal copper deficiency can result in embryonic and fetal abnormalities
    • Suspected idiopathic copper toxicosis - serum copper and ceruloplasmin levels are normal or slightly elevated. 
    • Suspected Indian childhood cirrhosis - plasma copper concentration may be normal or elevated
    • Suspected Menkes syndrome - serum copper < 11 micromoles/L (< 70 micrograms/dL)
    • Suspected Wilson disease - typically present with hypocupremia (40 to 60 mcg/dL), low ceruloplasmin levels and an increase in urinary copper excretion.
    Drug-Lab Interactions
    • Results increased in:  women, patients with dilated cardiomyopathy, immediately after myocardial infarction. 
    • Diurnal variations occur with highest levels noted in the morning.
    Procedure
    • Collect serum in a metal-free container or plastic syringe using a stainless steel needle.
    Storage and Handling
    • Store sample in a plastic vial or metal-free container.
    References
    • LaGow B et al., eds. PDR Lab Advisor. A Comprehensive Point-of-Care Guide for Over 600 Lab Tests.  First ed. Montvale, NJ: Thomson PDR; 2007.

MESH Terms & Keywords

  • Copper